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10.7150/ijms.20809 http://scihub22266oqcxt.onion/10.7150/ijms.20809 C5599924!5599924!28924372     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28924372&cmd=llinks): Failed to open stream: HTTP request failed! 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IL-36? inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis |pdf=|usr=}}{{28924372}} gab.com Text IL-36 inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis JO: Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28924372 #FOAvip Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte inflammation and differentiation that has a major impact on patients' quality of life. IL-36?, a member of IL-36 cytokine family, is highly expressed in psoriasis and plays an important role in inflammation response and differentiation. However, the function of IL-36? in differentiation and inflammation of keratinocyte in psoriasis has not been clearly identified. Thus, this study aimed to investigate the role of IL-36? on differentiation and inflammation in HaCaT cells. HaCaT cells were divided into three groups: (1) Control group; (2) IL-36? (100 ng/mL) group; (3) IL-36? (100 ng/mL) + IWP-2 (1?M) group. Real time PCR was used to detect gene expression; the inflammation cytokines were examined by ELISA. We showed that treatment of HaCaT cells with IL-36? significantly upregulated the expression levels of ?-catenin, cyclin D1, and ki-67. IL-36? also promoted the production of the inflammatory cytokines IFN-?, IL-1? and IL-6, suppressed the expression of filaggrin, involucrin, keratin 1 and keratin 5. Meanwhile, we demonstrated the role of IWP-2, an inhibitor of the Wnt signaling pathway, in IL-36?-treated HaCaT cells. Collectively, our findings suggest that IL-36? inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis, this indicated that downregulation of IL-36? may be a potential therapeutic option in psoriasis. Twit Text FOAVip IL-36 inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis ????Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28924372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28924372 #FOAvip English Wikipedia <ref>{{Cite pmid|28924372}}</ref> IL-36? inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis #MMPMID28924372 Wang W; Yu X; Wu C; Jin H Int J Med Sci 2017[]; 14 (10): 1002-7 PMID28924372show ga Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte inflammation and differentiation that has a major impact on patients' quality of life. IL-36?, a member of IL-36 cytokine family, is highly expressed in psoriasis and plays an important role in inflammation response and differentiation. However, the function of IL-36? in differentiation and inflammation of keratinocyte in psoriasis has not been clearly identified. Thus, this study aimed to investigate the role of IL-36? on differentiation and inflammation in HaCaT cells. HaCaT cells were divided into three groups: (1) Control group; (2) IL-36? (100 ng/mL) group; (3) IL-36? (100 ng/mL) + IWP-2 (1?M) group. Real time PCR was used to detect gene expression; the inflammation cytokines were examined by ELISA. We showed that treatment of HaCaT cells with IL-36? significantly upregulated the expression levels of ?-catenin, cyclin D1, and ki-67. IL-36? also promoted the production of the inflammatory cytokines IFN-?, IL-1? and IL-6, suppressed the expression of filaggrin, involucrin, keratin 1 and keratin 5. Meanwhile, we demonstrated the role of IWP-2, an inhibitor of the Wnt signaling pathway, in IL-36?-treated HaCaT cells. Collectively, our findings suggest that IL-36? inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis, this indicated that downregulation of IL-36? may be a potential therapeutic option in psoriasis. äIL-36? inhibits differentiation and induces inflammation of keratinocy(epmc).pdf DeepDyve Pubget Overpricing