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10.1038/s41598-017-12349-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-12349-9 C5605699!5605699!28928392     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28928392&cmd=llinks): Failed to open stream: HTTP request failed! 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Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis |pdf=|usr=}}{{28928392}} gab.com Text Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28928392 #FOAvip Emerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood. Consequently, this protein has not been therapeutically targeted for the treatment of RA. MALT1 plays a role in the paracaspase pathway, has proteolytic activity and is involved in the regulation of inflammatory responses. In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]p henylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor ?. Furthermore, MI-2 ameliorates pathologic bone erosion and synovitis in an in vivo mouse model of collagen-induced arthritis. Mechanistically, MI-2 blocked expression of the master osteoclast regulator ? nuclear factor of activated T cells 1 (NFATc1) ? by inhibiting nuclear factor ?B (NF-?B), which is a critical regulator of NFATc1. These findings highlight the important regulatory role of MALT1 in the NF-?B?NFATc1-signalling axis during osteoclastogenesis and suggest that targeting MALT1 is a promising treatment option for rheumatoid arthritis. Twit Text FOAVip Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28928392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28928392 #FOAvip English Wikipedia <ref>{{Cite pmid|28928392}}</ref> Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis #MMPMID28928392 Lee CH; Bae SJ; Kim M Sci Rep 2017[]; 7 (ä): ä PMID28928392show ga Emerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood. Consequently, this protein has not been therapeutically targeted for the treatment of RA. MALT1 plays a role in the paracaspase pathway, has proteolytic activity and is involved in the regulation of inflammatory responses. In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]p henylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor ?. Furthermore, MI-2 ameliorates pathologic bone erosion and synovitis in an in vivo mouse model of collagen-induced arthritis. Mechanistically, MI-2 blocked expression of the master osteoclast regulator ? nuclear factor of activated T cells 1 (NFATc1) ? by inhibiting nuclear factor ?B (NF-?B), which is a critical regulator of NFATc1. These findings highlight the important regulatory role of MALT1 in the NF-?B?NFATc1-signalling axis during osteoclastogenesis and suggest that targeting MALT1 is a promising treatment option for rheumatoid arthritis. äMucosa-associated lymphoid tissue lymphoma translocation 1 as a novel (epmc).pdf DeepDyve Pubget Overpricing