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10.1016/j.bbrep.2017.08.005 http://scihub22266oqcxt.onion/10.1016/j.bbrep.2017.08.005 C5613220!5613220!28955792     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28955792&cmd=llinks): Failed to open stream: HTTP request failed! 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STAT3 and NF-?B are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema |pdf=|usr=}}{{28955792}} gab.com Text STAT3 and NF- B are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema JO: Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=28955792 #FOAvip Cycloxygenase-2 (COX-2) is the inducible isoform of cycloxygenase enzyme family that catalyzes synthesis of inflammatory mediators, prostanoids and prostaglandins, and therefore, can be targeted by anti-inflammatory drugs. Here, we showed a plant polyphenol, kaempferol, attenuated IL-6-induced COX-2 expression in human monocytic THP-1 cells suggesting its beneficial role in chronic inflammation. Kaempferol deactivated and prevented nuclear localization of two major transcription factors STAT3 and NF-?B, mutually responsible for COX-2 induction in response to IL-6. Moreover, STAT3 and NF-?B were simultaneously deactivated by kaempferol in acute inflammation, as shown by carrageenan-induced mouse paw edema model. The concomitant reduction in COX-2 expression in paw tissues suggested kaempferol?s role in mitigation of inflammation by targeting STAT3 and NF-?B. Twit Text FOAVip STAT3 and NF- B are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema ????Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=28955792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28955792 #FOAvip English Wikipedia <ref>{{Cite pmid|28955792}}</ref> STAT3 and NF-?B are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema #MMPMID28955792 Basu A; Das AS; Sharma M; Pathak MP; Chattopadhyay P; Biswas K; Mukhopadhyay R Biochem Biophys Rep 2017[Dec]; 12 (ä): 54-61 PMID28955792show ga Cycloxygenase-2 (COX-2) is the inducible isoform of cycloxygenase enzyme family that catalyzes synthesis of inflammatory mediators, prostanoids and prostaglandins, and therefore, can be targeted by anti-inflammatory drugs. Here, we showed a plant polyphenol, kaempferol, attenuated IL-6-induced COX-2 expression in human monocytic THP-1 cells suggesting its beneficial role in chronic inflammation. Kaempferol deactivated and prevented nuclear localization of two major transcription factors STAT3 and NF-?B, mutually responsible for COX-2 induction in response to IL-6. Moreover, STAT3 and NF-?B were simultaneously deactivated by kaempferol in acute inflammation, as shown by carrageenan-induced mouse paw edema model. The concomitant reduction in COX-2 expression in paw tissues suggested kaempferol?s role in mitigation of inflammation by targeting STAT3 and NF-?B. äSTAT3 and NF-?B are common targets for kaempferol-mediated attenuation(epmc).pdf DeepDyve Pubget Overpricing