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10.1038/s41598-017-13455-4 http://scihub22266oqcxt.onion/10.1038/s41598-017-13455-4 C5635033!5635033!29018285     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29018285&cmd=llinks): Failed to open stream: HTTP request failed! 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The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid |pdf=|usr=}}{{29018285}} gab.com Text The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29018285 #FOAvip Perivascular spaces play a pivotal role in the exchange between cerebrospinal and interstitial fluids, and in the clearance of waste in the CNS, yet their precise anatomical components are not well described. The aim of this study was to characterise the ultrastructure of perivascular spaces and their role in the transport of fluid, in the spinal cord of healthy rats, using transmission electron microscopy. The distribution of cerebrospinal fluid tracers injected into the subarachnoid space was studied using light, confocal and electron microscopy. Perivascular spaces were found around arterioles and venules, but not capillaries, throughout the spinal cord white and grey matter. They contained fibroblasts and collagen fibres, and were continuous with the extracellular spaces of the surrounding tissue. At 5?min post injection, tracers were seen in the subarachnoid space, the peripheral white matter, the perivascular spaces, basement membranes, extracellular spaces of the surrounding tissue, and surprisingly, in the lumen of blood vessels, suggesting trans-vascular clearance. These findings point out an unrecognised outflow pathway for CNS fluids, with potential implications for volume regulation in health and disease states, but also clinically for the detection of CNS-derived biomarkers in plasma, the immune response and drug pharmacokinetics. Twit Text FOAVip The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29018285 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29018285 #FOAvip English Wikipedia <ref>{{Cite pmid|29018285}}</ref> The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid #MMPMID29018285 Lam MA; Hemley SJ; Najafi E; Vella NGF; Bilston LE; Stoodley MA Sci Rep 2017[]; 7 (�): � PMID29018285show ga Perivascular spaces play a pivotal role in the exchange between cerebrospinal and interstitial fluids, and in the clearance of waste in the CNS, yet their precise anatomical components are not well described. The aim of this study was to characterise the ultrastructure of perivascular spaces and their role in the transport of fluid, in the spinal cord of healthy rats, using transmission electron microscopy. The distribution of cerebrospinal fluid tracers injected into the subarachnoid space was studied using light, confocal and electron microscopy. Perivascular spaces were found around arterioles and venules, but not capillaries, throughout the spinal cord white and grey matter. They contained fibroblasts and collagen fibres, and were continuous with the extracellular spaces of the surrounding tissue. At 5?min post injection, tracers were seen in the subarachnoid space, the peripheral white matter, the perivascular spaces, basement membranes, extracellular spaces of the surrounding tissue, and surprisingly, in the lumen of blood vessels, suggesting trans-vascular clearance. These findings point out an unrecognised outflow pathway for CNS fluids, with potential implications for volume regulation in health and disease states, but also clinically for the detection of CNS-derived biomarkers in plasma, the immune response and drug pharmacokinetics. �The ultrastructure of spinal cord perivascular spaces: Implications fo(epmc).pdf DeepDyve Pubget Overpricing