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10.1073/pnas.1702223114 http://scihub22266oqcxt.onion/10.1073/pnas.1702223114 C5642679!5642679!28973855     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28973855&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28973855.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (41): E8675-84 Nephropedia Template TP {{tp|p=28973855|t=2017. Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow |pdf=|usr=}}{{28973855}} gab.com Text Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28973855 #FOAvip Atherosclerotic plaques tend to develop preferentially in areas of the vasculature exposed to low and disturbed shear stress (SS), but the mechanisms are not fully understood. In this study, we demonstrate that inefficient autophagy contributes to the development of atherosclerotic plaques in low-SS areas. Defective endothelial autophagy not only curbs endothelial alignment with the direction of blood flow, but also promotes an inflammatory, apoptotic, and senescent phenotype. Furthermore, genetic inactivation of endothelial autophagy in a murine model of atherosclerosis increases plaque burden exclusively in high-SS areas that are normally resistant to atherosclerotic plaque development. Altogether, these findings underline the role of endothelial autophagic flux activation by SS as an atheroprotective mechanism. Twit Text FOAVip Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28973855 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28973855 #FOAvip English Wikipedia <ref>{{Cite pmid|28973855}}</ref> Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow #MMPMID28973855 Vion AC; Kheloufi M; Hammoutene A; Poisson J; Lasselin J; Devue C; Pic I; Dupont N; Busse J; Stark K; Lafaurie-Janvore J; Barakat AI; Loyer X; Souyri M; Viollet B; Julia P; Tedgui A; Codogno P; Boulanger CM; Rautou PE Proc Natl Acad Sci U S A 2017[Oct]; 114 (41): E8675-84 PMID28973855show ga Atherosclerotic plaques tend to develop preferentially in areas of the vasculature exposed to low and disturbed shear stress (SS), but the mechanisms are not fully understood. In this study, we demonstrate that inefficient autophagy contributes to the development of atherosclerotic plaques in low-SS areas. Defective endothelial autophagy not only curbs endothelial alignment with the direction of blood flow, but also promotes an inflammatory, apoptotic, and senescent phenotype. Furthermore, genetic inactivation of endothelial autophagy in a murine model of atherosclerosis increases plaque burden exclusively in high-SS areas that are normally resistant to atherosclerotic plaque development. Altogether, these findings underline the role of endothelial autophagic flux activation by SS as an atheroprotective mechanism. �Autophagy is required for endothelial cell alignment and atheroprotect(epmc).pdf DeepDyve Pubget Overpricing