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10.1038/cti.2017.42 http://scihub22266oqcxt.onion/10.1038/cti.2017.42 C5671989!5671989!29114386     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29114386&cmd=llinks): Failed to open stream: HTTP request failed! 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Suppression of inflammation and tissue damage by a hookworm recombinant protein in experimental colitis |pdf=|usr=}}{{29114386}} gab.com Text Suppression of inflammation and tissue damage by a hookworm recombinant protein in experimental colitis JO: Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=29114386 #FOAvip Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis. Colitic inflammation assessed by weight loss, colon atrophy, oedema, ulceration and necrosis, as well as abdominal adhesion was significantly suppressed in mice treated with a single intraperitoneal dose of AIP-1 at 1?mg?kg?1. Local infiltration of inflammatory cells was also significantly reduced, with minimal goblet cell loss and preserved mucosal architecture. Treatment with AIP-1 promoted the production of colon interleukin (IL)-10, transforming growth factor (TGF)-? and thymic stromal lymphopoietin (TSLP), resulting in the suppression of tumour necrosis factor (TNF)-?, IL-13 and IL-17?A cytokines and granulocyte macrophage colony-stimulating factor (GM-CSF), CX motif chemokine (CXCL)-11 and cyclooxygenase synthase (COX)-2 mRNA transcripts. AIP-1 promoted the accumulation of regulatory T cells in the colon likely allowing rapid healing of the colon mucosa. Hookworm recombinant AIP-1 is a novel therapeutic candidate for the treatment of inflammatory bowel diseases that can be explored for the prevention of acute inflammatory relapses, an important cause of colorectal cancer. Twit Text FOAVip Suppression of inflammation and tissue damage by a hookworm recombinant protein in experimental colitis ????Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=29114386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29114386 #FOAvip English Wikipedia <ref>{{Cite pmid|29114386}}</ref> Suppression of inflammation and tissue damage by a hookworm recombinant protein in experimental colitis #MMPMID29114386 Ferreira IB; Pickering DA; Troy S; Croese J; Loukas A; Navarro S Clin Transl Immunology 2017[Oct]; 6 (10): e157- PMID29114386show ga Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis. Colitic inflammation assessed by weight loss, colon atrophy, oedema, ulceration and necrosis, as well as abdominal adhesion was significantly suppressed in mice treated with a single intraperitoneal dose of AIP-1 at 1?mg?kg?1. Local infiltration of inflammatory cells was also significantly reduced, with minimal goblet cell loss and preserved mucosal architecture. Treatment with AIP-1 promoted the production of colon interleukin (IL)-10, transforming growth factor (TGF)-? and thymic stromal lymphopoietin (TSLP), resulting in the suppression of tumour necrosis factor (TNF)-?, IL-13 and IL-17?A cytokines and granulocyte macrophage colony-stimulating factor (GM-CSF), CX motif chemokine (CXCL)-11 and cyclooxygenase synthase (COX)-2 mRNA transcripts. AIP-1 promoted the accumulation of regulatory T cells in the colon likely allowing rapid healing of the colon mucosa. Hookworm recombinant AIP-1 is a novel therapeutic candidate for the treatment of inflammatory bowel diseases that can be explored for the prevention of acute inflammatory relapses, an important cause of colorectal cancer. �Suppression of inflammation and tissue damage by a hookworm recombinan(epmc).pdf DeepDyve Pubget Overpricing