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10.1073/pnas.1613140114 http://scihub22266oqcxt.onion/10.1073/pnas.1613140114 C5699024!5699024!29087297     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29087297&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29087297.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (46): 12190-5 Nephropedia Template TP {{tp|p=29087297|t=2017. Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination |pdf=|usr=}}{{29087297}} gab.com Text Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29087297 #FOAvip Antigen discrimination by T cells is based on subtle differences in binding of the T cell receptor (TCR) for its peptide major histocompatibility complex (pMHC) ligand. While such binding characteristics are readily mapped with great precision in reconstituted biochemical systems, it is less clear how these interactions are affected in the live cell environment. Here we utilize single-molecule imaging to individually resolve all of the pMHC:TCR binding events in live T cells. The quantitative measurements reveal an active feedback mechanism that globally modulates the probability of pMHC:TCR binding throughout the cell?cell interface, without affecting the unbinding rate. The result is to increase the efficiency with which TCRs scan for antigen pMHC after the first few molecular encounters have occurred. Twit Text FOAVip Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29087297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29087297 #FOAvip English Wikipedia <ref>{{Cite pmid|29087297}}</ref> Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination #MMPMID29087297 Pielak RM; O?Donoghue GP; Lin JJ; Alfieri KN; Fay NC; Low-Nam ST; Groves JT Proc Natl Acad Sci U S A 2017[Nov]; 114 (46): 12190-5 PMID29087297show ga Antigen discrimination by T cells is based on subtle differences in binding of the T cell receptor (TCR) for its peptide major histocompatibility complex (pMHC) ligand. While such binding characteristics are readily mapped with great precision in reconstituted biochemical systems, it is less clear how these interactions are affected in the live cell environment. Here we utilize single-molecule imaging to individually resolve all of the pMHC:TCR binding events in live T cells. The quantitative measurements reveal an active feedback mechanism that globally modulates the probability of pMHC:TCR binding throughout the cell?cell interface, without affecting the unbinding rate. The result is to increase the efficiency with which TCRs scan for antigen pMHC after the first few molecular encounters have occurred. �Early T cell receptor signals globally modulate ligand:receptor affini(epmc).pdf DeepDyve Pubget Overpricing