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10.3109/14767058.2015.1020293 http://scihub22266oqcxt.onion/10.3109/14767058.2015.1020293 C5704947!5704947!26373262     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26373262&cmd=llinks): Failed to open stream: HTTP request failed! 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A New Antimicrobial Combination Prolongs the Latency Period, Reduces Acute Histologic Chorioamnionitis and Funisitis, and Improves Neonatal Outcomes in Preterm PROM |pdf=|usr=}}{{26373262}} gab.com Text A New Antimicrobial Combination Prolongs the Latency Period, Reduces Acute Histologic Chorioamnionitis and Funisitis, and Improves Neonatal Outcomes in Preterm PROM JO: J Matern Fetal Neonatal Med http://www.kidney.de/pget.php?&tw=1&pmid=26373262 #FOAvip Objective: Antibiotic administration is a standard practice in preterm premature rupture of membranes (PROM). Specific antimicrobial agents often include ampicillin and/or erythromycin. Anaerobes and genital mycoplasmas are frequently involved in preterm PROM, but are not adequately covered by antibiotics routinely used in clinical practice. Our objective was to compare the outcomes of PROM treated with standard antibiotic administration versus a new combination more effective against these bacteria. Study Design: A retrospective study compared perinatal outcomes in 314 patients with PROM <34 weeks receiving antimicrobial regimen 1 (ampicillin and/or cephalosporins; n=195, 1993?2003) versus regimen 2 (ceftriaxone, clarithromycin, and metronidazole; n=119, 2003?2012). Intra-amniotic infection/inflammation was assessed by positive amniotic fluid culture and/or an elevated amniotic fluid MMP-8 concentration (>23ng/mL). Results: 1) Patients treated with regimen 2 had a longer median antibiotic-to-delivery interval than those with regimen 1 [median (interquartile range) 23 days (10?51 days) versus 12 days (5?52 days), p<0.01]; 2) patients who received regimen 2 had lower rates of acute histologic chorioamnionitis (50.5% vs. 66.7%, p<0.05) and funisitis (13.9% versus 42.9%, p<0.001) than those who had received regimen 1; 3) the rates of intra-ventricular hemorrhage (IVH) and cerebral palsy (CP) were significantly lower in patients allocated to regimen 2 than regimen 1 (IVH: 2.1% versus 19.0%, p<0.001 and CP: 0% vs. 5.7%, p<0.05); and 4) subgroup analysis showed that regimen 2 improved perinatal outcomes in pregnancies with intra-amniotic infection/inflammation, but not in those without intra-amniotic infection/inflammation (after adjusting for gestational age and antenatal corticosteroid administration). Conclusion: A new antibiotic combination consisting of ceftriaxone, clarithromycin, and metronidazole prolonged the latency period, reduced acute histologic chorioamnionitis/funisitis, and improved neonatal outcomes in patients with preterm PROM. These findings suggest that the combination of antimicrobial agents (ceftriaxone, clarithromycin, and metronidazole) may improve perinatal outcome in preterm PROM. Twit Text FOAVip A New Antimicrobial Combination Prolongs the Latency Period, Reduces Acute Histologic Chorioamnionitis and Funisitis, and Improves Neonatal Outcomes in Preterm PROM ????J Matern Fetal Neonatal Med http://www.kidney.de/pget.php?&tw=1&pmid=26373262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26373262 #FOAvip English Wikipedia <ref>{{Cite pmid|26373262}}</ref> A New Antimicrobial Combination Prolongs the Latency Period, Reduces Acute Histologic Chorioamnionitis and Funisitis, and Improves Neonatal Outcomes in Preterm PROM #MMPMID26373262 Lee J; Romero R; Kim SM; Chaemsaithong P; Park CW; Park JS; Jun JK; Yoon BH J Matern Fetal Neonatal Med 2016[Mar]; 29 (5): 707-20 PMID26373262show ga Objective: Antibiotic administration is a standard practice in preterm premature rupture of membranes (PROM). Specific antimicrobial agents often include ampicillin and/or erythromycin. Anaerobes and genital mycoplasmas are frequently involved in preterm PROM, but are not adequately covered by antibiotics routinely used in clinical practice. Our objective was to compare the outcomes of PROM treated with standard antibiotic administration versus a new combination more effective against these bacteria. Study Design: A retrospective study compared perinatal outcomes in 314 patients with PROM <34 weeks receiving antimicrobial regimen 1 (ampicillin and/or cephalosporins; n=195, 1993?2003) versus regimen 2 (ceftriaxone, clarithromycin, and metronidazole; n=119, 2003?2012). Intra-amniotic infection/inflammation was assessed by positive amniotic fluid culture and/or an elevated amniotic fluid MMP-8 concentration (>23ng/mL). Results: 1) Patients treated with regimen 2 had a longer median antibiotic-to-delivery interval than those with regimen 1 [median (interquartile range) 23 days (10?51 days) versus 12 days (5?52 days), p<0.01]; 2) patients who received regimen 2 had lower rates of acute histologic chorioamnionitis (50.5% vs. 66.7%, p<0.05) and funisitis (13.9% versus 42.9%, p<0.001) than those who had received regimen 1; 3) the rates of intra-ventricular hemorrhage (IVH) and cerebral palsy (CP) were significantly lower in patients allocated to regimen 2 than regimen 1 (IVH: 2.1% versus 19.0%, p<0.001 and CP: 0% vs. 5.7%, p<0.05); and 4) subgroup analysis showed that regimen 2 improved perinatal outcomes in pregnancies with intra-amniotic infection/inflammation, but not in those without intra-amniotic infection/inflammation (after adjusting for gestational age and antenatal corticosteroid administration). Conclusion: A new antibiotic combination consisting of ceftriaxone, clarithromycin, and metronidazole prolonged the latency period, reduced acute histologic chorioamnionitis/funisitis, and improved neonatal outcomes in patients with preterm PROM. These findings suggest that the combination of antimicrobial agents (ceftriaxone, clarithromycin, and metronidazole) may improve perinatal outcome in preterm PROM. �A New Antimicrobial Combination Prolongs the Latency Period, Reduces A(epmc).pdf DeepDyve Pubget Overpricing