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10.1038/s41598-018-20241-3 http://scihub22266oqcxt.onion/10.1038/s41598-018-20241-3 C5794996!5794996!29391410     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29391410&cmd=llinks): Failed to open stream: HTTP request failed! 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Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation |pdf=|usr=}}{{29391410}} gab.com Text Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29391410 #FOAvip Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular effects of magnesium on hydroxyapatite formation are largely neglected. This study investigated the effects of magnesium on intracellular changes associated with transdifferentiation and extracellular crystal formation. Bovine vascular smooth muscle cells were calcified using ?-glycerophosphate. Transcriptional analysis, alkaline phosphatase activity and detection of apoptosis were used to identify transdifferentiation. Using X-ray diffraction and energy dispersive spectroscopy extracellular crystal composition was investigated. Magnesium prevented calcification in vascular smooth muscle cells. ?-glycerophosphate increased expression of osteopontin but no other genes related to calcification. Alkaline phosphatase activity was stable and apoptosis was only detected after calcification independent of magnesium. Blocking of the magnesium channel TRPM7 using 2-APB did not abrogate the protective effects of magnesium. Magnesium prevented the formation of hydroxyapatite, which formed extensively during ?-glycerophosphate treatment. Magnesium reduced calcium and phosphate fractions of 68% and 41% extracellular crystals, respectively, without affecting the fraction of magnesium. This study demonstrates that magnesium inhibits hydroxyapatite formation in the extracellular space, thereby preventing calcification of vascular smooth muscle cells. Twit Text FOAVip Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29391410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29391410 #FOAvip English Wikipedia <ref>{{Cite pmid|29391410}}</ref> Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation #MMPMID29391410 ter Braake AD; Tinnemans PT; Shanahan CM; Hoenderop JGJ; de Baaij JHF Sci Rep 2018[]; 8 (ä): ä PMID29391410show ga Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular effects of magnesium on hydroxyapatite formation are largely neglected. This study investigated the effects of magnesium on intracellular changes associated with transdifferentiation and extracellular crystal formation. Bovine vascular smooth muscle cells were calcified using ?-glycerophosphate. Transcriptional analysis, alkaline phosphatase activity and detection of apoptosis were used to identify transdifferentiation. Using X-ray diffraction and energy dispersive spectroscopy extracellular crystal composition was investigated. Magnesium prevented calcification in vascular smooth muscle cells. ?-glycerophosphate increased expression of osteopontin but no other genes related to calcification. Alkaline phosphatase activity was stable and apoptosis was only detected after calcification independent of magnesium. Blocking of the magnesium channel TRPM7 using 2-APB did not abrogate the protective effects of magnesium. Magnesium prevented the formation of hydroxyapatite, which formed extensively during ?-glycerophosphate treatment. Magnesium reduced calcium and phosphate fractions of 68% and 41% extracellular crystals, respectively, without affecting the fraction of magnesium. This study demonstrates that magnesium inhibits hydroxyapatite formation in the extracellular space, thereby preventing calcification of vascular smooth muscle cells. äMagnesium prevents vascular calcification in vitro by inhibition of hy(epmc).pdf DeepDyve Pubget Overpricing