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10.1038/s41420-017-0016-3 http://scihub22266oqcxt.onion/10.1038/s41420-017-0016-3 C5841362!5841362!29531814     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29531814.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Discov 2018 ; 4 (ä): ä Nephropedia Template TP {{tp|p=29531814|t=2018. 2-aminopurine suppresses the TGF-?1-induced epithelial?mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis |pdf=|usr=}}{{29531814}} gab.com Text 2-aminopurine suppresses the TGF- 1-induced epithelial mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis JO: Cell Death Discov http://www.kidney.de/pget.php?&tw=1&pmid=29531814 #FOAvip The epithelial?mesenchymal transition (EMT) is a multifunctional cell process involved in the pathogenesis of numerous conditions, including fibrosis and cancer. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by fibroblast accumulation and collagen deposition in the lungs. The fibroblasts involved in this process partially originate from lung epithelial cells via the EMT. Evidence suggests that the EMT contributes to progression, invasion, and metastasis of various types of cancer. We screened a series of 80 compounds for the ability to interfere with the EMT and potentially be applied as a therapeutic for IPF and/or lung cancer. We identified 2-aminopurine (2-AP), a fluorescent analog of guanosine and adenosine, as a candidate in this screen. Herein, we demonstrate that 2-AP can restore E-cadherin expression and inhibit fibronectin and vimentin expression in TGF-?1?treated A549 lung cancer cells. Moreover, 2-AP can inhibit TGF-?1-induced metastasis of A549 cells. This compound significantly attenuated bleomycin (BLM)-induced pulmonary inflammation, the EMT, and fibrosis. In addition, 2-AP treatment significantly decreased mortality in a mouse model of pulmonary fibrosis. Collectively, we determined that 2-AP could inhibit metastasis in vitro by suppressing the TGF-?1-induced EMT and could attenuate BLM-induced pulmonary fibrosis in vivo. Results of this study suggest that 2-AP may have utility as a treatment for lung cancer and pulmonary fibrosis. Twit Text FOAVip 2-aminopurine suppresses the TGF- 1-induced epithelial mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis ????Cell Death Discov http://www.kidney.de/pget.php?&tw=1&pmid=29531814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29531814 #FOAvip English Wikipedia <ref>{{Cite pmid|29531814}}</ref> 2-aminopurine suppresses the TGF-?1-induced epithelial?mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis #MMPMID29531814 Weng D; Chen Jx; Li Hh; Liu F; Zhou Ld; Liu Hp; Zheng Rj; Jiang Y; Liu Zh; Ge B Cell Death Discov 2018[]; 4 (ä): ä PMID29531814show ga The epithelial?mesenchymal transition (EMT) is a multifunctional cell process involved in the pathogenesis of numerous conditions, including fibrosis and cancer. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by fibroblast accumulation and collagen deposition in the lungs. The fibroblasts involved in this process partially originate from lung epithelial cells via the EMT. Evidence suggests that the EMT contributes to progression, invasion, and metastasis of various types of cancer. We screened a series of 80 compounds for the ability to interfere with the EMT and potentially be applied as a therapeutic for IPF and/or lung cancer. We identified 2-aminopurine (2-AP), a fluorescent analog of guanosine and adenosine, as a candidate in this screen. Herein, we demonstrate that 2-AP can restore E-cadherin expression and inhibit fibronectin and vimentin expression in TGF-?1?treated A549 lung cancer cells. Moreover, 2-AP can inhibit TGF-?1-induced metastasis of A549 cells. This compound significantly attenuated bleomycin (BLM)-induced pulmonary inflammation, the EMT, and fibrosis. In addition, 2-AP treatment significantly decreased mortality in a mouse model of pulmonary fibrosis. Collectively, we determined that 2-AP could inhibit metastasis in vitro by suppressing the TGF-?1-induced EMT and could attenuate BLM-induced pulmonary fibrosis in vivo. Results of this study suggest that 2-AP may have utility as a treatment for lung cancer and pulmonary fibrosis. ä2-aminopurine suppresses the TGF-?1-induced epithelial?mesenchymal tra(epmc).pdf DeepDyve Pubget Overpricing