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10.1371/journal.pone.0193970

http://scihub22266oqcxt.onion/10.1371/journal.pone.0193970
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C5854356!5854356!29543836
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suck abstract from ncbi


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pmid29543836      PLoS+One 2018 ; 13 (3): ä
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  • Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil?Microglia interaction during stroke in vivo #MMPMID29543836
  • Neumann J; Henneberg S; von Kenne S; Nolte N; Müller AJ; Schraven B; Görtler MW; Reymann KG; Gunzer M; Riek-Burchardt M
  • PLoS One 2018[]; 13 (3): ä PMID29543836show ga
  • Inflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.
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