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10.18632/oncotarget.24022 http://scihub22266oqcxt.onion/10.18632/oncotarget.24022 C5862577!5862577!29568356     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29568356&cmd=llinks): Failed to open stream: HTTP request failed! 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Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice |pdf=|usr=}}{{29568356}} gab.com Text Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568356 #FOAvip Bacterial lipopolysaccharide (LPS) contributes to airway inflammation and mucus hypersecretion in chronic airway inflammatory diseases, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Neutrophil extracellular traps (NETs) are extracellular meshworks composed of DNA fibers and antimicrobial proteins. Although NET formation has been detected in COPD and CF patients, how NETs contribute to these diseases is poorly understood. This study was performed to clarify the effects and mechanisms of action of NETs in airway inflammation and mucus hypersecretion. We created a murine model of LPS-induced airway inflammation and mucus hypersecretion, and found that LPS-induced NET formation was degraded by aerosolized DNase I treatment in mice. Degradation of NETs by aerosolized DNase I reduced LPS-induced airway inflammation and mucus hypersecretion in mice, this reduction correlated with suppression of TLR4/NF-?B signaling pathway. More importantly, NETs promoted LPS-induced production of IL-1?, IL-6 and TNF-? in macrophages. These results suggest NET degradation using aerosolized DNase I is a potential new therapeutic strategy for treating COPD and CF. Twit Text FOAVip Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29568356 #FOAvip English Wikipedia <ref>{{Cite pmid|29568356}}</ref> Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice #MMPMID29568356 Zou Y; Chen X; Xiao J; Bo Zhou D; Xiao Lu X; Li W; Xie B; Kuang X; Chen Q Oncotarget 2018[Mar]; 9 (17): 13276-86 PMID29568356show ga Bacterial lipopolysaccharide (LPS) contributes to airway inflammation and mucus hypersecretion in chronic airway inflammatory diseases, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Neutrophil extracellular traps (NETs) are extracellular meshworks composed of DNA fibers and antimicrobial proteins. Although NET formation has been detected in COPD and CF patients, how NETs contribute to these diseases is poorly understood. This study was performed to clarify the effects and mechanisms of action of NETs in airway inflammation and mucus hypersecretion. We created a murine model of LPS-induced airway inflammation and mucus hypersecretion, and found that LPS-induced NET formation was degraded by aerosolized DNase I treatment in mice. Degradation of NETs by aerosolized DNase I reduced LPS-induced airway inflammation and mucus hypersecretion in mice, this reduction correlated with suppression of TLR4/NF-?B signaling pathway. More importantly, NETs promoted LPS-induced production of IL-1?, IL-6 and TNF-? in macrophages. These results suggest NET degradation using aerosolized DNase I is a potential new therapeutic strategy for treating COPD and CF. äNeutrophil extracellular traps promote lipopolysaccharide-induced airw(epmc).pdf DeepDyve Pubget Overpricing