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10.1080/14787210.2017.1372192 http://scihub22266oqcxt.onion/10.1080/14787210.2017.1372192 C5870900!5870900!28837368     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28837368&cmd=llinks): Failed to open stream: HTTP request failed! 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Advances in the Local and Targeted Delivery of Anti-infective Agents for Management of Osteomyelitis |pdf=|usr=}}{{28837368}} gab.com Text Advances in the Local and Targeted Delivery of Anti-infective Agents for Management of Osteomyelitis JO: Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=28837368 #FOAvip Introduction: Osteomyelitis, a common and debilitating invasive infection of bone, is a frequent complication following orthopedic surgery and causes pathologic destruction of skeletal tissues. Bone destruction during osteomyelitis results in necrotic tissue, which is poorly penetrated by antibiotics and can serve as a nidus for relapsing infection. Osteomyelitis therefore frequently necessitates surgical debridement procedures, which provide a unique opportunity for targeted delivery of antimicrobial and adjunctive therapies. Areas Covered: Following surgical debridement, tissue voids require implanted materials to facilitate the healing process. Antibiotic-loaded, non-biodegradable implants have been the standard of care. However, a new generation of biodegradable, osteoconductive materials are being developed. Additionally, in the face of widespread antimicrobial resistance, alternative therapies to traditional antibiotic regimens are being investigated, including bone targeting compounds, antimicrobial surface modifications of orthopedic implants, and anti-virulence strategies. Expert Commentary: Recent advances in biodegradable drug delivery scaffolds make this technology an attractive alternative to traditional techniques for orthopedic infection that require secondary operations for removal. Advances in novel treatment methods are expanding the arsenal of viable antimicrobial treatment strategies in the face of widespread drug resistance. Despite a need for large scale clinical investigations, these strategies offer hope for future treatment of this difficult invasive disease. Twit Text FOAVip Advances in the Local and Targeted Delivery of Anti-infective Agents for Management of Osteomyelitis ????Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=28837368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28837368 #FOAvip English Wikipedia <ref>{{Cite pmid|28837368}}</ref> Advances in the Local and Targeted Delivery of Anti-infective Agents for Management of Osteomyelitis #MMPMID28837368 Ford CA; Cassat JE Expert Rev Anti Infect Ther 2017[Sep]; 15 (9): 851-60 PMID28837368show ga Introduction: Osteomyelitis, a common and debilitating invasive infection of bone, is a frequent complication following orthopedic surgery and causes pathologic destruction of skeletal tissues. Bone destruction during osteomyelitis results in necrotic tissue, which is poorly penetrated by antibiotics and can serve as a nidus for relapsing infection. Osteomyelitis therefore frequently necessitates surgical debridement procedures, which provide a unique opportunity for targeted delivery of antimicrobial and adjunctive therapies. Areas Covered: Following surgical debridement, tissue voids require implanted materials to facilitate the healing process. Antibiotic-loaded, non-biodegradable implants have been the standard of care. However, a new generation of biodegradable, osteoconductive materials are being developed. Additionally, in the face of widespread antimicrobial resistance, alternative therapies to traditional antibiotic regimens are being investigated, including bone targeting compounds, antimicrobial surface modifications of orthopedic implants, and anti-virulence strategies. Expert Commentary: Recent advances in biodegradable drug delivery scaffolds make this technology an attractive alternative to traditional techniques for orthopedic infection that require secondary operations for removal. Advances in novel treatment methods are expanding the arsenal of viable antimicrobial treatment strategies in the face of widespread drug resistance. Despite a need for large scale clinical investigations, these strategies offer hope for future treatment of this difficult invasive disease. �Advances in the Local and Targeted Delivery of Anti-infective Agents f(epmc).pdf DeepDyve Pubget Overpricing