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10.1038/s41413-018-0009-8 http://scihub22266oqcxt.onion/10.1038/s41413-018-0009-8 C5884797!5884797!29644114     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29644114&cmd=llinks): Failed to open stream: HTTP request failed! 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Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma |pdf=|usr=}}{{29644114}} gab.com Text Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma JO: Bone Res http://www.kidney.de/pget.php?&tw=1&pmid=29644114 #FOAvip Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically, THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. Twit Text FOAVip Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma ????Bone Res http://www.kidney.de/pget.php?&tw=1&pmid=29644114 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29644114 #FOAvip English Wikipedia <ref>{{Cite pmid|29644114}}</ref> Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma #MMPMID29644114 Chen D; Zhao Z; Huang Z; Chen DC; Zhu XX; Wang YZ; Yan YW; Tang S; Madhavan S; Ni W; Huang Zp; Li W; Ji W; Shen H; Lin S; Jiang YZ Bone Res 2018[]; 6 (ä): ä PMID29644114show ga Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically, THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. äSuper enhancer inhibitors suppress MYC driven transcriptional amplific(epmc).pdf DeepDyve Pubget Overpricing