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10.1186/s13075-018-1568-1 http://scihub22266oqcxt.onion/10.1186/s13075-018-1568-1 C5894134!5894134!29636091     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29636091.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arthritis+Res+Ther 2018 ; 20 (ä): ä Nephropedia Template TP {{tp|p=29636091|t=2018. Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons |pdf=|usr=}}{{29636091}} gab.com Text Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=29636091 #FOAvip Background: Innate immunity including macrophages (M?) in lupus nephritis (LN) has been gaining attention, but roles of M? in LN remain uncertain. Methods: Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-inflammatory property), pSTAT1, and CMAF-expressing M? in the glomeruli of patients with LN. Effects of type I interferons on the expression levels of CD163, HO-1, BTB and CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, and IL-10 by human M2-like M?, which were differentiated in vitro from peripheral monocytes with macrophage colony-stimulating factor, were assessed by RT-PCR and immunocytostaining. Clinical manifestations, anti-double-stranded DNA (anti-dsDNA), and local HO-1 expression were compared in Bach1-deficient and wild-type MRL/lpr mice. Results: The number of glomerular M2-like M? correlated with the amounts of proteinuria in patients with LN. Unlike monocyte-derived M2-like M?, HO-1 expression was defective in the majority of glomerular M2-like M? of patients with LN. Stimulation of human M2-like M? with type I interferons led to reduced HO-1 expression and increased Bach1 and IL-6 expression. Bach1-deficient MRL/lpr mice exhibited increased HO-1 expression in kidneys, prolonged survival, reduced urine proteins, and serum blood urea nitrogen levels, but serum anti-dsDNA antibody levels were comparable. Increased expression of CD163 and HO-1 was found in peritoneal M? from Bach1-deficient MRL/lpr mice. Conclusions: Our data suggest that dysregulated M2-like M? play a proinflammatory role in LN. Bach1 is a potential therapeutic target that could restore the anti-inflammatory property of M2 M?. Electronic supplementary material: The online version of this article (10.1186/s13075-018-1568-1) contains supplementary material, which is available to authorized users. Twit Text FOAVip Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=29636091 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29636091 #FOAvip English Wikipedia <ref>{{Cite pmid|29636091}}</ref> Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons #MMPMID29636091 Kishimoto D; Kirino Y; Tamura M; Takeno M; Kunishita Y; Takase-Minegishi K; Nakano H; Kato I; Nagahama K; Yoshimi R; Igarashi K; Aoki I; Nakajima H Arthritis Res Ther 2018[]; 20 (ä): ä PMID29636091show ga Background: Innate immunity including macrophages (M?) in lupus nephritis (LN) has been gaining attention, but roles of M? in LN remain uncertain. Methods: Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-inflammatory property), pSTAT1, and CMAF-expressing M? in the glomeruli of patients with LN. Effects of type I interferons on the expression levels of CD163, HO-1, BTB and CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, and IL-10 by human M2-like M?, which were differentiated in vitro from peripheral monocytes with macrophage colony-stimulating factor, were assessed by RT-PCR and immunocytostaining. Clinical manifestations, anti-double-stranded DNA (anti-dsDNA), and local HO-1 expression were compared in Bach1-deficient and wild-type MRL/lpr mice. Results: The number of glomerular M2-like M? correlated with the amounts of proteinuria in patients with LN. Unlike monocyte-derived M2-like M?, HO-1 expression was defective in the majority of glomerular M2-like M? of patients with LN. Stimulation of human M2-like M? with type I interferons led to reduced HO-1 expression and increased Bach1 and IL-6 expression. Bach1-deficient MRL/lpr mice exhibited increased HO-1 expression in kidneys, prolonged survival, reduced urine proteins, and serum blood urea nitrogen levels, but serum anti-dsDNA antibody levels were comparable. Increased expression of CD163 and HO-1 was found in peritoneal M? from Bach1-deficient MRL/lpr mice. Conclusions: Our data suggest that dysregulated M2-like M? play a proinflammatory role in LN. Bach1 is a potential therapeutic target that could restore the anti-inflammatory property of M2 M?. Electronic supplementary material: The online version of this article (10.1186/s13075-018-1568-1) contains supplementary material, which is available to authorized users. äDysregulated heme oxygenase-1low M2-like macrophages augment lupus nep(epmc).pdf DeepDyve Pubget Overpricing