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10.1007/s00125-010-1866-x http://scihub22266oqcxt.onion/10.1007/s00125-010-1866-x C5894805!5894805!20694718     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20694718.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetologia 2010 ; 53 (11): 2352-6 Nephropedia Template TP {{tp|p=20694718|t=2010. A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose intolerant phenotype in the mouse |pdf=|usr=}}{{20694718}} gab.com Text A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose intolerant phenotype in the mouse JO: Diabetologia http://www.kidney.de/pget.php?&tw=1&pmid=20694718 #FOAvip Aims/hypothesis: We identified a mouse with a point mutation (Y12STOP) in the KCNJ11 subunit of the KATP channel that is identical to that found in a patient with congenital hyperinsulinism of infancy (HI). We aimed to characterise the phenotype arising from this loss-of-function mutation and to compare it to that of other mouse models and patients with HI. Methods: An N-ethyl-N-nitrosourea (ENU) induced mutation on a C3H/HeH background (Kcnj11Y12STOP) was phenotyped using intraperitoneal glucose tolerance testing measuring both glucose and insulin plasma concentrations. Insulin secretion and response to incretins was measured on isolated islets. Results: Homozygous male and female adult Kcnj11Y12STOP mice exhibit impaired glucose tolerance and a defect in insulin secretion measured both in vivo and in vitro. Islets had an impaired incretin response and reduced insulin content. Conclusions/interpretation: The phenotype of homozygous Kcnj11Y12STOP mice is consistent with that of other Kcnj11 knockout mouse models. In contrast to the patient carrying this mutation homozygously, we did not observe hyperinsulinaemia or hypoglycaemia. It has been reported that HI patients may develop diabetes and our mouse model may reflect this clinical feature. The Kcnj11Y12STOP model may thus be useful in further studies of KATP channel function in various cell types and in the investigation of the development of hyperglycaemia in HI patients. Twit Text FOAVip A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose intolerant phenotype in the mouse ????Diabetologia http://www.kidney.de/pget.php?&tw=1&pmid=20694718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20694718 #FOAvip English Wikipedia <ref>{{Cite pmid|20694718}}</ref> A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose intolerant phenotype in the mouse #MMPMID20694718 Hugill A; Shimomura K; Ashcroft FM; Cox RD Diabetologia 2010[Nov]; 53 (11): 2352-6 PMID20694718show ga Aims/hypothesis: We identified a mouse with a point mutation (Y12STOP) in the KCNJ11 subunit of the KATP channel that is identical to that found in a patient with congenital hyperinsulinism of infancy (HI). We aimed to characterise the phenotype arising from this loss-of-function mutation and to compare it to that of other mouse models and patients with HI. Methods: An N-ethyl-N-nitrosourea (ENU) induced mutation on a C3H/HeH background (Kcnj11Y12STOP) was phenotyped using intraperitoneal glucose tolerance testing measuring both glucose and insulin plasma concentrations. Insulin secretion and response to incretins was measured on isolated islets. Results: Homozygous male and female adult Kcnj11Y12STOP mice exhibit impaired glucose tolerance and a defect in insulin secretion measured both in vivo and in vitro. Islets had an impaired incretin response and reduced insulin content. Conclusions/interpretation: The phenotype of homozygous Kcnj11Y12STOP mice is consistent with that of other Kcnj11 knockout mouse models. In contrast to the patient carrying this mutation homozygously, we did not observe hyperinsulinaemia or hypoglycaemia. It has been reported that HI patients may develop diabetes and our mouse model may reflect this clinical feature. The Kcnj11Y12STOP model may thus be useful in further studies of KATP channel function in various cell types and in the investigation of the development of hyperglycaemia in HI patients. äA mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a(epmc).pdf DeepDyve Pubget Overpricing