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10.7554/eLife.32963 http://scihub22266oqcxt.onion/10.7554/eLife.32963 C5896879!5896879!29638214     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29638214&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29638214.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       eLife 2018 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29638214|t=2018. Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima |pdf=|usr=}}{{29638214}} gab.com Text Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=29638214 #FOAvip Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of binding (?G). To determine the molecular mechanism behind this effect, we solved the structures of human HOXB13 and CDX2 bound to their two optimal DNA sequences, CAATAAA and TCGTAAA. Thermodynamic analyses by isothermal titration calorimetry revealed that both sites were bound with similar ?G. However, the interaction with the CAA sequence was driven by change in enthalpy (?H), whereas the TCG site was bound with similar affinity due to smaller loss of entropy (?S). This thermodynamic mechanism that leads to at least two local optima likely affects many macromolecular interactions, as ?G depends on two partially independent variables ?H and ?S according to the central equation of thermodynamics, ?G = ?H - T?S. Twit Text FOAVip Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=29638214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29638214 #FOAvip English Wikipedia <ref>{{Cite pmid|29638214}}</ref> Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima #MMPMID29638214 Morgunova E; Yin Y; Das PK; Jolma A; Zhu F; Popov A; Xu Y; Nilsson L; Taipale J eLife 2018[]; 7 (ä): ä PMID29638214show ga Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of binding (?G). To determine the molecular mechanism behind this effect, we solved the structures of human HOXB13 and CDX2 bound to their two optimal DNA sequences, CAATAAA and TCGTAAA. Thermodynamic analyses by isothermal titration calorimetry revealed that both sites were bound with similar ?G. However, the interaction with the CAA sequence was driven by change in enthalpy (?H), whereas the TCG site was bound with similar affinity due to smaller loss of entropy (?S). This thermodynamic mechanism that leads to at least two local optima likely affects many macromolecular interactions, as ?G depends on two partially independent variables ?H and ?S according to the central equation of thermodynamics, ?G = ?H - T?S. äTwo distinct DNA sequences recognized by transcription factors represe(epmc).pdf DeepDyve Pubget Overpricing