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A case report of sofosbuvir and daclatasvirto treat a patient with acute hepatitis C virus genotype 2 monoinfection #MMPMID29642211
Li C; Hu J
Medicine (Baltimore) 2018[Apr]; 97 (15): ä PMID29642211show ga
Rationale:: Direct-acting antivirals (DAAs) are the first-line treatment for patients with chronic hepatitis C virus (HCV) infection. However, its effects on patients with acute HCV infection are poorly understood, and the data for treatment of DAAs for genotype 2 acute monoinfection patients with HCV are lacking. Patient concerns:: In this case report, a 26 year-old Chinese female acquired a tattoo and developed fatigue, nausea, and anorexia. Laboratory tests showed abnormal liver function. Diagnoses:: Five months after the patient acquired a tattoo, laboratory tests showed anti-HCV antibody titers were 26.0?s/co, HCV RNA was 5.74×105?IU/mL, and HCV genotype was 2a. The patient was diagnosed with acute hepatitis C (AHC). Interventions:: HCV RNA did not have spontaneous clearance 12 weeks after the infection of the patient. The patient received sofosbuvir (SOF) and daclatasvir (DCV) combination treatment for 12 weeks. Outcomes:: Laboratory tests showed HCV RNA was undetectable at weeks 4, and anti-HCV antibody was in seroconversion at weeks 12 during treatment. The patient achieved a sustained virological response 36 weeks after the end of treatment. Lessons:: Patients with acute HCV genotype 2 monoinfection would benefit from antiviral treatment with SOF and DCV.