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10.1038/s41598-018-24741-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-24741-0 C5915484!5915484!29691439     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29691439&cmd=llinks): Failed to open stream: HTTP request failed! 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Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |pdf=|usr=}}{{29691439}} gab.com Text Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29691439 #FOAvip Accumulation of amyloid-? plaques and tau contribute to the pathogenesis of Alzheimer?s disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-? causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an essential antioxidant element reduced in the aging brain, prevents development of neuropathology in AD transgenic mice at early disease stages. The therapeutic potential of selenium for ameliorating or reversing neuropsychiatric and cognitive behavioral symptoms at late AD stages is largely unknown. Here, we evaluated the effects of chronic dietary sodium selenate supplementation for 4 months in female 3xTg-AD mice at 12?14 months of age. Chronic sodium selenate treatment efficiently reversed hippocampal-dependent learning and memory impairments, and behavior- and neuropsychiatric-like symptoms in old female 3xTg-AD mice. Selenium significantly decreased the number�of�aggregated tau-positive neurons and astrogliosis, without globally affecting amyloid plaques, in the hippocampus of 3xTg-AD mice. These results indicate that selenium treatment reverses AD-like memory and neuropsychiatric symptoms by a mechanism involving reduction of aggregated tau and/or reactive astrocytes but not amyloid pathology. These results suggest that sodium selenate could be part of a combined therapeutic approach for the treatment of memory and neuropsychiatric symptoms in advanced AD stages. Twit Text FOAVip Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29691439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29691439 #FOAvip English Wikipedia <ref>{{Cite pmid|29691439}}</ref> Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice #MMPMID29691439 Van der Jeugd A; Parra-Damas A; Baeta-Corral R; Soto-Fagu�s CM; Ahmed T; LaFerla FM; Gim�nez-Llort L; D?Hooge R; Saura CA Sci Rep 2018[]; 8 (�): � PMID29691439show ga Accumulation of amyloid-? plaques and tau contribute to the pathogenesis of Alzheimer?s disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-? causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an essential antioxidant element reduced in the aging brain, prevents development of neuropathology in AD transgenic mice at early disease stages. The therapeutic potential of selenium for ameliorating or reversing neuropsychiatric and cognitive behavioral symptoms at late AD stages is largely unknown. Here, we evaluated the effects of chronic dietary sodium selenate supplementation for 4 months in female 3xTg-AD mice at 12?14 months of age. Chronic sodium selenate treatment efficiently reversed hippocampal-dependent learning and memory impairments, and behavior- and neuropsychiatric-like symptoms in old female 3xTg-AD mice. Selenium significantly decreased the number�of�aggregated tau-positive neurons and astrogliosis, without globally affecting amyloid plaques, in the hippocampus of 3xTg-AD mice. These results indicate that selenium treatment reverses AD-like memory and neuropsychiatric symptoms by a mechanism involving reduction of aggregated tau and/or reactive astrocytes but not amyloid pathology. These results suggest that sodium selenate could be part of a combined therapeutic approach for the treatment of memory and neuropsychiatric symptoms in advanced AD stages. �Reversal of memory and neuropsychiatric symptoms and reduced tau patho(epmc).pdf DeepDyve Pubget Overpricing