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Effect of Pravastatin, a Potent 3?Hydroxy?3?methylgliitaryl?coenzyme A Reductase Inhibitor, on Survival of AH130 Hepatoma?bearing Rats #MMPMID1483925
Jpn J Cancer Res 1992[Nov]; 83 (11): 1120-3 PMID1483925show ga
3?Hydroxy?3?methylglutaryl?coenzyme A (HMG?CoA) reductase inhibitor is known to have an inhibitory effect on cell growth in addition to a cholesterol?lowering effect. This study examined the effect of pravastatin, a potent inhibitor of HMG?CoA reductase, on the survival of AH130 hepatoma?bearing rats. Pravastatin (1, 2, or 8 mg/kg body weight) was intraperitoneally injected once a day into tumor?bearing rats. The difference in the survival curves was significant between the controls and the rats treated with S mg/kg of pravastatin (P < 0.019 by logrank test) but not between the controls and the rats treated with 1 or 2 mg/kg of the inhibitor. The tumor volume was significantly decreased in the rats treated with 8 mg/kg of pravastatin (P < 0.05). These observations showed that intraperitoneal injection of pravastatin could improve the survival of AH130 hepatoma?bearing rats and had an inhibitory effect on the growth of the ascites form tumor.