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10.1111/j.1349-7006.1992.tb00122.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1992.tb00122.x C5918839!5918839!1506275     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\1506275.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Jpn+J+Cancer+Res 1992 ; 83 (4): 402-9 Nephropedia Template TP {{tp|p=1506275|t=1992. Cell?killing Activity and Kinetic Analysis of a Novel Antitumor Compound NC?190, a Benzo a phenazine Derivative |pdf=|usr=}}{{1506275}} gab.com Text Cell killing Activity and Kinetic Analysis of a Novel Antitumor Compound NC 190, a Benzo a phenazine Derivative JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1506275 #FOAvip A novel antitumor compound, N???dimethylaminoethyl 9?carboxy?5?hydroxy?10?methoxybenzo[a]?phenazine?6?carboxamide sodium salt (NC?190), was evaluated for antitumor activity in vitro against cultured tumor cell lines, and the kinetics of cell killing was elucidated. NC?190 strongly inhibited the growth of all of 3 murine tumor cell lines, 7 human tumor cell lines and 2 normal cell lines. With continuous exposure, the 50% inhibition concentrations were in the range of 0.005?0.06 ?g/ml, except for KATO?III (2.15 ? g/ml). By colony?forming assay, concentrations of NC?190 giving 90% cell kill (IC90) at various exposure times were obtained with HeLa S3 cells. The plot of IC90exposure time on a log?log scale was linear for NC?190 with a slope of ?1, which is typical for cell cycle phase?nonspecific agents. A 2 h treatment with NC?190 induced a rapid reduction in cell viability at doses of more than 3 ? g/ml. At the dose where colony formation was completely inhibited, cell viability was persistently reduced to below 20% during the cell culture period. NC?190 cauced a dose? and time?dependent reduction in DNA synthesis. The inhibitions of RNA and protein synthesis were less than that of DNA synthesis. Spectroscopic studies of NC?190 mixed with calf thymus DNA demonstrated that NC?190 was capable of interacting with DNA. However, DNA thermal denaturation studies suggested that intercalation of NC?190 was weak in comparison with those of classical intercalating drugs. Twit Text FOAVip Cell killing Activity and Kinetic Analysis of a Novel Antitumor Compound NC 190, a Benzo a phenazine Derivative ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1506275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1506275 #FOAvip English Wikipedia <ref>{{Cite pmid|1506275}}</ref> Cell?killing Activity and Kinetic Analysis of a Novel Antitumor Compound NC?190, a Benzo a phenazine Derivative #MMPMID1506275 Nakaike S; Yamagishi T; Nanaumi K; Otomo S; Tsukagoshi S Jpn J Cancer Res 1992[Apr]; 83 (4): 402-9 PMID1506275show ga A novel antitumor compound, N???dimethylaminoethyl 9?carboxy?5?hydroxy?10?methoxybenzo[a]?phenazine?6?carboxamide sodium salt (NC?190), was evaluated for antitumor activity in vitro against cultured tumor cell lines, and the kinetics of cell killing was elucidated. NC?190 strongly inhibited the growth of all of 3 murine tumor cell lines, 7 human tumor cell lines and 2 normal cell lines. With continuous exposure, the 50% inhibition concentrations were in the range of 0.005?0.06 ?g/ml, except for KATO?III (2.15 ? g/ml). By colony?forming assay, concentrations of NC?190 giving 90% cell kill (IC90) at various exposure times were obtained with HeLa S3 cells. The plot of IC90exposure time on a log?log scale was linear for NC?190 with a slope of ?1, which is typical for cell cycle phase?nonspecific agents. A 2 h treatment with NC?190 induced a rapid reduction in cell viability at doses of more than 3 ? g/ml. At the dose where colony formation was completely inhibited, cell viability was persistently reduced to below 20% during the cell culture period. NC?190 cauced a dose? and time?dependent reduction in DNA synthesis. The inhibitions of RNA and protein synthesis were less than that of DNA synthesis. Spectroscopic studies of NC?190 mixed with calf thymus DNA demonstrated that NC?190 was capable of interacting with DNA. However, DNA thermal denaturation studies suggested that intercalation of NC?190 was weak in comparison with those of classical intercalating drugs. äCell?killing Activity and Kinetic Analysis of a Novel Antitumor Compou(epmc).pdf DeepDyve Pubget Overpricing