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10.1073/pnas.1720948115 http://scihub22266oqcxt.onion/10.1073/pnas.1720948115 C5924916!5924916!29632196     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29632196.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (17): E4041-50 Nephropedia Template TP {{tp|p=29632196|t=2018. Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti?PD-1 treatment |pdf=|usr=}}{{29632196}} gab.com Text Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti PD-1 treatment JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29632196 #FOAvip Cancer immunotherapy is a promising therapeutic intervention. However, complete and durable responses are seen in only a fraction of cancer patients. A key factor that limits therapeutic success is the lack of T cells in tumor cell regions, a profile termed ?immune-excluded.? Here, we provide evidence that tumor-associated macrophages (TAMs) are an important determinant of the establishment of a T cell-excluded tumor phenotype. In human and murine tumors, we found that CD8 T cells poorly migrate and invade tumor nests due to long-lasting interactions with TAMs. The depletion of TAMs restores T cell migration and infiltration into tumor islets and improves the efficacy of anti?PD-1 immunotherapy. This study highlights the rationale of combining approaches targeting TAM and immune checkpoint proteins. Twit Text FOAVip Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti PD-1 treatment ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29632196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632196 #FOAvip English Wikipedia <ref>{{Cite pmid|29632196}}</ref> Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti?PD-1 treatment #MMPMID29632196 Peranzoni E; Lemoine J; Vimeux L; Feuillet V; Barrin S; Kantari-Mimoun C; Bercovici N; Guérin M; Biton J; Ouakrim H; Régnier F; Lupo A; Alifano M; Damotte D; Donnadieu E Proc Natl Acad Sci U S A 2018[Apr]; 115 (17): E4041-50 PMID29632196show ga Cancer immunotherapy is a promising therapeutic intervention. However, complete and durable responses are seen in only a fraction of cancer patients. A key factor that limits therapeutic success is the lack of T cells in tumor cell regions, a profile termed ?immune-excluded.? Here, we provide evidence that tumor-associated macrophages (TAMs) are an important determinant of the establishment of a T cell-excluded tumor phenotype. In human and murine tumors, we found that CD8 T cells poorly migrate and invade tumor nests due to long-lasting interactions with TAMs. The depletion of TAMs restores T cell migration and infiltration into tumor islets and improves the efficacy of anti?PD-1 immunotherapy. This study highlights the rationale of combining approaches targeting TAM and immune checkpoint proteins. äMacrophages impede CD8 T cells from reaching tumor cells and limit the(epmc).pdf DeepDyve Pubget Overpricing