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10.1186/s11658-018-0086-0 http://scihub22266oqcxt.onion/10.1186/s11658-018-0086-0 C5932757!5932757!29743895     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29743895&cmd=llinks): Failed to open stream: HTTP request failed! 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Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress |pdf=|usr=}}{{29743895}} gab.com Text Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress JO: Cell Mol Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29743895 #FOAvip Background: Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored. In the present study, a collagen-induced arthritis rat model, IL-1?-stimulated SW982 cells, and RA-like fibroblast-like synoviocytes (FLS) were employed to investigate the effect and possible mechanism of osthole on arthritis in vivo and in vitro. Results: 20 and 40�mg/kg osthole significantly alleviated collagen-induced arthritic symptoms based on histopathology and clinical arthritis scores, and improved erosion using HE staining. 20 and 40�mg/kg osthole decreased the level of IL-1?, TNF-? and IL-6 in rats and ameliorated oxidative stress in serum evaluated using ELISA kits. In addition, treatment with 50 and 100�?M osthole for 48�h inhibited 10�ng/ml IL-1?-stimulated proliferation and migration of SW982, and significantly inhibited the expression of matrix metalloproteinases, such as MMP-1, MMP-3 and MMP-13, as detected by western blot. 50 and 100�?M osthole also blocked the generation of IL-6 and TNF-? in IL-1?-stimulated SW982 cells. The NF-?B and MAPK pathways were also inhibited by osthole in IL-1?-treated SW982 cells. Conclusion: These results collectively demonstrated that osthole improves collagen-induced arthritis in a rat model and IL-1?-treated SW982 cells through inhibiting inflammation and cellular stress in vivo and in vitro, and osthole might be a promising therapeutic agent for RA. Twit Text FOAVip Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress ????Cell Mol Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29743895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29743895 #FOAvip English Wikipedia <ref>{{Cite pmid|29743895}}</ref> Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress #MMPMID29743895 Xu R; Liu Z; Hou J; Huang T; Yang M Cell Mol Biol Lett 2018[]; 23 (�): � PMID29743895show ga Background: Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored. In the present study, a collagen-induced arthritis rat model, IL-1?-stimulated SW982 cells, and RA-like fibroblast-like synoviocytes (FLS) were employed to investigate the effect and possible mechanism of osthole on arthritis in vivo and in vitro. Results: 20 and 40�mg/kg osthole significantly alleviated collagen-induced arthritic symptoms based on histopathology and clinical arthritis scores, and improved erosion using HE staining. 20 and 40�mg/kg osthole decreased the level of IL-1?, TNF-? and IL-6 in rats and ameliorated oxidative stress in serum evaluated using ELISA kits. In addition, treatment with 50 and 100�?M osthole for 48�h inhibited 10�ng/ml IL-1?-stimulated proliferation and migration of SW982, and significantly inhibited the expression of matrix metalloproteinases, such as MMP-1, MMP-3 and MMP-13, as detected by western blot. 50 and 100�?M osthole also blocked the generation of IL-6 and TNF-? in IL-1?-stimulated SW982 cells. The NF-?B and MAPK pathways were also inhibited by osthole in IL-1?-treated SW982 cells. Conclusion: These results collectively demonstrated that osthole improves collagen-induced arthritis in a rat model and IL-1?-treated SW982 cells through inhibiting inflammation and cellular stress in vivo and in vitro, and osthole might be a promising therapeutic agent for RA. �Osthole improves collagen-induced arthritis in a rat model through inh(epmc).pdf DeepDyve Pubget Overpricing