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10.1002/mnfr.201700139

http://scihub22266oqcxt.onion/10.1002/mnfr.201700139
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suck abstract from ncbi


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pmid28556482      Mol+Nutr+Food+Res 2017 ; 61 (10): ä
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  • Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice #MMPMID28556482
  • Suk S; Kwon GT; Lee E; Jang WJ; Yang H; Kim JH; Thimmegowda NR; Chung MY; Kwon JY; Yang S; Kim JK; Park JHY; Lee KW
  • Mol Nutr Food Res 2017[Oct]; 61 (10): ä PMID28556482show ga
  • Scope: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI). Methods and results: Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 ?M). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines. Conclusion: These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.
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