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10.22038/IJBMS.2018.27510.6714 http://scihub22266oqcxt.onion/10.22038/IJBMS.2018.27510.6714 C5960758!5960758!29796225     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29796225&cmd=llinks): Failed to open stream: HTTP request failed! 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The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats |pdf=|usr=}}{{29796225}} gab.com Text The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats JO: Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=29796225 #FOAvip Objective(s):: 5-fluorouracil-induced (5-FU), an anticarcinogenic agent, is reported to have side-effects that include hepatotoxicity and nephrotoxicity. The study objective was to investigate the protective effects of naringin on 5-FU-induced hepatotoxicity and nephrotoxicity. Materials and Methods:: Thirty rodents were assigned to three groups. The control group received 1 ml of intragastric distilled water for 14 days. The 5-FU group received 1 ml of distilled water for 14 days as a placebo. On day 9, this same group received a 20 mg/kg dose of 5-FU administered intraperitoneally(IP) for a further five days. The naringin+5-FU group received a 100 mg/kg dose of naringin (IP) for 14 days. On day 9, 20 mg/kg of 5-FU was administered (IP) to this group for a further five days. On day 15, the rats were decapitated, and blood and renal and hepatic tissues were taken. Results:: It was determined that serum creatinine, BUN, AST, ALT, ALP, and LDH levels, as well as cytokine levels in the liver and kidney tissues were significantly elevated in the 5-FU group, compared to the control group. The comparative values were similar in the control and naringin+5-FU groups. When the liver tissue was examined histopathologically, in the control group it was found to be normal in structure. However, necrosis was observed in the hepatocytes of the pericentric region in the 5-FU group. 8-OHdG cell density was significantly elevated in the 5-FU group, compared to the control and naringin+5-FU groups. Conclusion:: Naringin was observed to have a protective effect on 5-FU-induced liver and kidney damage. Twit Text FOAVip The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats ????Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=29796225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29796225 #FOAvip English Wikipedia <ref>{{Cite pmid|29796225}}</ref> The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats #MMPMID29796225 Gelen V; ?eng�l E; Y?ld?r?m S; Atila G Iran J Basic Med Sci 2018[Apr]; 21 (4): 404-10 PMID29796225show ga Objective(s):: 5-fluorouracil-induced (5-FU), an anticarcinogenic agent, is reported to have side-effects that include hepatotoxicity and nephrotoxicity. The study objective was to investigate the protective effects of naringin on 5-FU-induced hepatotoxicity and nephrotoxicity. Materials and Methods:: Thirty rodents were assigned to three groups. The control group received 1 ml of intragastric distilled water for 14 days. The 5-FU group received 1 ml of distilled water for 14 days as a placebo. On day 9, this same group received a 20 mg/kg dose of 5-FU administered intraperitoneally(IP) for a further five days. The naringin+5-FU group received a 100 mg/kg dose of naringin (IP) for 14 days. On day 9, 20 mg/kg of 5-FU was administered (IP) to this group for a further five days. On day 15, the rats were decapitated, and blood and renal and hepatic tissues were taken. Results:: It was determined that serum creatinine, BUN, AST, ALT, ALP, and LDH levels, as well as cytokine levels in the liver and kidney tissues were significantly elevated in the 5-FU group, compared to the control group. The comparative values were similar in the control and naringin+5-FU groups. When the liver tissue was examined histopathologically, in the control group it was found to be normal in structure. However, necrosis was observed in the hepatocytes of the pericentric region in the 5-FU group. 8-OHdG cell density was significantly elevated in the 5-FU group, compared to the control and naringin+5-FU groups. Conclusion:: Naringin was observed to have a protective effect on 5-FU-induced liver and kidney damage. �The protective effects of naringin against 5-fluorouracil-induced hepa(epmc).pdf DeepDyve Pubget Overpricing