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10.1016/j.conctc.2018.05.013 http://scihub22266oqcxt.onion/10.1016/j.conctc.2018.05.013 C6022251!6022251!30023455     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30023455&cmd=llinks): Failed to open stream: HTTP request failed! 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Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology |pdf=|usr=}}{{30023455}} gab.com Text Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology JO: Contemp Clin Trials Commun http://www.kidney.de/pget.php?&tw=1&pmid=30023455 #FOAvip Aims: The secreted form of the ?-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults. FIT-AGEING will also investigate the physiological consequences of activating the klotho gene (secondary outcomes). Methods: FIT-AGEING will recruit 80 sedentary, healthy adults (50% women) aged 45?65 years old. Eligible participants will be randomly assigned to a non-exercise group, i.e. the control group, (n?=?20), a physical activity recommendation from World Health Organization group (n?=?20), a high intensity interval training group (n?=?20), and a whole-body electromyostimulation group (n?=?20). The laboratory measurements will be taken at the baseline and 12 weeks later including the S-Klotho plasma levels, physical fitness (cardiorespiratory fitness, muscular strength), body composition, basal metabolic rate, heart rate variability, maximal fat oxidation, health blood biomarkers, free-living physical activity, sleep habits, reaction time, cognitive variables, and health-related questionnaires. We will also obtain dietary habits data and cardiovascular disease risk factors. Twit Text FOAVip Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology ????Contemp Clin Trials Commun http://www.kidney.de/pget.php?&tw=1&pmid=30023455 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30023455 #FOAvip English Wikipedia <ref>{{Cite pmid|30023455}}</ref> Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology #MMPMID30023455 Amaro-Gahete FJ; De-la-O A; Jurado-Fasoli L; Espuch-Oliver A; Robles-Gonzalez L; Navarro-Lomas G; de Haro T; Femia P; Castillo MJ; Gutierrez A Contemp Clin Trials Commun 2018[Sep]; 11 (�): 10-9 PMID30023455show ga Aims: The secreted form of the ?-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults. FIT-AGEING will also investigate the physiological consequences of activating the klotho gene (secondary outcomes). Methods: FIT-AGEING will recruit 80 sedentary, healthy adults (50% women) aged 45?65 years old. Eligible participants will be randomly assigned to a non-exercise group, i.e. the control group, (n?=?20), a physical activity recommendation from World Health Organization group (n?=?20), a high intensity interval training group (n?=?20), and a whole-body electromyostimulation group (n?=?20). The laboratory measurements will be taken at the baseline and 12 weeks later including the S-Klotho plasma levels, physical fitness (cardiorespiratory fitness, muscular strength), body composition, basal metabolic rate, heart rate variability, maximal fat oxidation, health blood biomarkers, free-living physical activity, sleep habits, reaction time, cognitive variables, and health-related questionnaires. We will also obtain dietary habits data and cardiovascular disease risk factors. �Exercise training as S-Klotho protein stimulator in sedentary healthy (epmc).pdf DeepDyve Pubget Overpricing