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10.3892/ijmm.2018.3674 http://scihub22266oqcxt.onion/10.3892/ijmm.2018.3674 C6034932!6034932!29767265     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29767265.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Med 2018 ; 42 (2): 926-34 Nephropedia Template TP {{tp|p=29767265|t=2018. Knockdown of TNF-? alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL-10 expression |pdf=|usr=}}{{29767265}} gab.com Text Knockdown of TNF- alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL-10 expression JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29767265 #FOAvip Intestinal ischemia and reperfusion (II/R) injury often triggers severe injury in remote organs, with the lungs being considered the main target. Excessive elevation of proinflammatory cytokines is a major contributor in the occurrence and development of II/R-induced acute lung injury (ALI). Therefore, the present study aimed to investigate whether blocking tumor necrosis factor-? (TNF-?) expression could protect the lungs from injury following II/R, and to explore the possible underlying mechanism involving interleukin-10 (IL-10). Briefly, II/R was induced in rats by 40 min occlusion of the superior mesenteric artery and celiac artery, followed by 8, 16 or 24 h of reperfusion. Subsequently, lentiviral vectors containing TNF-? short hairpin (sh)RNA were injected into the right lung tissues, in order to induce TNF-? knockdown. The severity of ALI was determined according to lung injury scores and lung edema (lung wet/dry weight ratio). The expression levels of TNF-? were analyzed by quantitative polymerase chain reaction (qPCR), western blotting and immunofluorescence (IF) staining. IL-10 expression, in response to TNF-? knockdown, was detected in lung tissues by qPCR and IF. The results detected marked inflammatory responses, and increased levels of lung wet/dry weight ratio and TNF-? expression, in the lungs of II/R rats. Conversely, treatment with TNF-? shRNA significantly alleviated the severity of ALI and upregulated the expression levels of IL-10 in lung tissues. These findings suggested that TNF-? RNA interference may exert a protective effect on II/R-induced ALI via the upregulation of IL-10. Therefore, TNF-? knockdown may be considered a potential strategy for the prevention or treatment of ALI induced by II/R in future clinical trials. Twit Text FOAVip Knockdown of TNF- alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL-10 expression ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29767265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29767265 #FOAvip English Wikipedia <ref>{{Cite pmid|29767265}}</ref> Knockdown of TNF-? alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL-10 expression #MMPMID29767265 Yang Z; Zhang XR; Zhao Q; Wang SL; Xiong LL; Zhang P; Yuan B; Zhang ZB; Fan SY; Wang TH; Zhang YH Int J Mol Med 2018[Aug]; 42 (2): 926-34 PMID29767265show ga Intestinal ischemia and reperfusion (II/R) injury often triggers severe injury in remote organs, with the lungs being considered the main target. Excessive elevation of proinflammatory cytokines is a major contributor in the occurrence and development of II/R-induced acute lung injury (ALI). Therefore, the present study aimed to investigate whether blocking tumor necrosis factor-? (TNF-?) expression could protect the lungs from injury following II/R, and to explore the possible underlying mechanism involving interleukin-10 (IL-10). Briefly, II/R was induced in rats by 40 min occlusion of the superior mesenteric artery and celiac artery, followed by 8, 16 or 24 h of reperfusion. Subsequently, lentiviral vectors containing TNF-? short hairpin (sh)RNA were injected into the right lung tissues, in order to induce TNF-? knockdown. The severity of ALI was determined according to lung injury scores and lung edema (lung wet/dry weight ratio). The expression levels of TNF-? were analyzed by quantitative polymerase chain reaction (qPCR), western blotting and immunofluorescence (IF) staining. IL-10 expression, in response to TNF-? knockdown, was detected in lung tissues by qPCR and IF. The results detected marked inflammatory responses, and increased levels of lung wet/dry weight ratio and TNF-? expression, in the lungs of II/R rats. Conversely, treatment with TNF-? shRNA significantly alleviated the severity of ALI and upregulated the expression levels of IL-10 in lung tissues. These findings suggested that TNF-? RNA interference may exert a protective effect on II/R-induced ALI via the upregulation of IL-10. Therefore, TNF-? knockdown may be considered a potential strategy for the prevention or treatment of ALI induced by II/R in future clinical trials. äKnockdown of TNF-? alleviates acute lung injury in rats with intestina(epmc).pdf DeepDyve Pubget Overpricing