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10.1038/s41467-018-05062-2 http://scihub22266oqcxt.onion/10.1038/s41467-018-05062-2 C6035189!6035189!29980671     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29980671&cmd=llinks): Failed to open stream: HTTP request failed! 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Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses |pdf=|usr=}}{{29980671}} gab.com Text Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29980671 #FOAvip Sepsis is a life-threatening condition caused by dysregulated host responses to infection. Widespread vascular hyperpermeability and a ?cytokine storm? are two pathophysiological hallmarks of sepsis. Here, we show that intermedin (IMD), a member of the calcitonin family, alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. IMD promotes the relocation of vascular endothelial cadherin through a Rab11-dependent pathway to dynamically repair the disrupted endothelial junction. Additionally, IMD decreases inflammatory responses by reducing macrophage infiltration via downregulating CCR2 expression. IMD peptide administration ameliorates organ injuries and significantly improves the survival of septic mice, and the experimental results correlate with the clinical data. Patients with high IMD levels exhibit a lower risk of shock, lower severity scores, and greatly improved survival outcomes than those with low IMD levels. Based on our data, IMD may be an important self-protective factor in response to sepsis. Twit Text FOAVip Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29980671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29980671 #FOAvip English Wikipedia <ref>{{Cite pmid|29980671}}</ref> Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses #MMPMID29980671 Xiao F; Wang D; Kong L; Li M; Feng Z; Shuai B; Wang L; Wei Y; Li H; Wu S; Tan C; Zhao H; Hu X; Liu J; Kang Y; Liao X; Zhou Y; Zhang W Nat Commun 2018[]; 9 (ä): ä PMID29980671show ga Sepsis is a life-threatening condition caused by dysregulated host responses to infection. Widespread vascular hyperpermeability and a ?cytokine storm? are two pathophysiological hallmarks of sepsis. Here, we show that intermedin (IMD), a member of the calcitonin family, alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. IMD promotes the relocation of vascular endothelial cadherin through a Rab11-dependent pathway to dynamically repair the disrupted endothelial junction. Additionally, IMD decreases inflammatory responses by reducing macrophage infiltration via downregulating CCR2 expression. IMD peptide administration ameliorates organ injuries and significantly improves the survival of septic mice, and the experimental results correlate with the clinical data. Patients with high IMD levels exhibit a lower risk of shock, lower severity scores, and greatly improved survival outcomes than those with low IMD levels. Based on our data, IMD may be an important self-protective factor in response to sepsis. äIntermedin protects against sepsis by concurrently re-establishing the(epmc).pdf DeepDyve Pubget Overpricing