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10.1038/s41598-018-28928-3 http://scihub22266oqcxt.onion/10.1038/s41598-018-28928-3 C6045671!6045671!30006603     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30006603&cmd=llinks): Failed to open stream: HTTP request failed! 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Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature |pdf=|usr=}}{{30006603}} gab.com Text Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30006603 #FOAvip The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value. Survival analyses were performed to identify independent predictors, taking into account the main clinical-pathological features affecting OS. Finally, independent predictors were correlated with YAP1 oncoprotein expression. At least one of the Hippo genes is an independent prognostic factor in 12 out of 13 considered tumor datasets. mRNA levels of the independent predictors coherently correlate with YAP1 in glioma, kidney renal clear cell, head and neck, and bladder cancer. Moreover, literature data revealed the association between YAP1 levels and OS in gastric, colorectal, hepatocellular, pancreatic, and lung cancer. Herein, we identified cancers in which Hippo pathway affects OS; these cancers should be candidates for YAP1 inhibitors development and testing. Twit Text FOAVip Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30006603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30006603 #FOAvip English Wikipedia <ref>{{Cite pmid|30006603}}</ref> Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature #MMPMID30006603 Poma AM; Torregrossa L; Bruno R; Basolo F; Fontanini G Sci Rep 2018[]; 8 (�): � PMID30006603show ga The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value. Survival analyses were performed to identify independent predictors, taking into account the main clinical-pathological features affecting OS. Finally, independent predictors were correlated with YAP1 oncoprotein expression. At least one of the Hippo genes is an independent prognostic factor in 12 out of 13 considered tumor datasets. mRNA levels of the independent predictors coherently correlate with YAP1 in glioma, kidney renal clear cell, head and neck, and bladder cancer. Moreover, literature data revealed the association between YAP1 levels and OS in gastric, colorectal, hepatocellular, pancreatic, and lung cancer. Herein, we identified cancers in which Hippo pathway affects OS; these cancers should be candidates for YAP1 inhibitors development and testing. �Hippo pathway affects survival of cancer patients: extensive analysis (epmc).pdf DeepDyve Pubget Overpricing