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10.1136/openhrt-2018-000803 http://scihub22266oqcxt.onion/10.1136/openhrt-2018-000803 C6045729!6045729!30018776     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30018776.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Open+Heart 2018 ; 5 (2): ä Nephropedia Template TP {{tp|p=30018776|t=2018. Association and diagnostic utility of diastolic dysfunction and myocardial fibrosis in patients with Fabry disease |pdf=|usr=}}{{30018776}} gab.com Text Association and diagnostic utility of diastolic dysfunction and myocardial fibrosis in patients with Fabry disease JO: Open Heart http://www.kidney.de/pget.php?&tw=1&pmid=30018776 #FOAvip Objectives: Current guidelines highlight important therapy implications of cardiac fibrosis in patients with Fabry disease (FD). However, association between morphological and functional impairments with cardiac fibrosis in hereditary cardiomyopathies remains elusive. We investigated the association between echocardiography-determined cardiac dysfunction and cardiac MRI (cMRI)-detected myocardial fibrosis (late gadolinium enhancement, LE) in patients with FD with preserved left ventricular ejection fraction (?50%). Methods: 146 patients with FD (aged 39±14 years, 57 men) were analysed, all receiving echocardiography and cMRI within a 1?week interval. Longitudinal systolic strain (LS_sys), strain rate (LSr_sys) and diastolic strain rate (LSr_E/LSr_A) were assessed using speckle-tracking imaging. Receiver operating characteristic (ROC) analysis was performed to identify the diagnostic performance of various markers for LE. Results: LE was detected in 57 (39%) patients with FD. LV wall thickness, left atrial volume, septal E/e?, diastolic dysfunction grade, global LS_sys and E/LSr_E, mid-lateral LS_sys and LSr_E, as well as N-terminal pro-brain natriuretic peptide were all associated with LE independent of age, sex, body mass index, New York Heart Association functional class and kidney function. In ROC curve analysis, septal E/e? performed best (area under the curve=0.86, 95% CI=0.79 to 0.92). Septal E/e?>14.8 was strongly associated with LE (specificity=97.8%?and sensitivity=49.1%). In 9% of patients, localised LE was present even though no other cardiac or kidney abnormalities were detected. Conclusions: Echocardiography-derived diastolic dysfunction is closely linked to LE in FD. Septal E/e? ratio is the best echocardiographic marker suggestive of LE. Diastolic dysfunction is not a prerequisite for LE in FD, since LE can be detected in the absence of measurable cardiac functional impairments. Trial registration number: ClinicalTrials.gov Identifier (NCT03362164). Twit Text FOAVip Association and diagnostic utility of diastolic dysfunction and myocardial fibrosis in patients with Fabry disease ????Open Heart http://www.kidney.de/pget.php?&tw=1&pmid=30018776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30018776 #FOAvip English Wikipedia <ref>{{Cite pmid|30018776}}</ref> Association and diagnostic utility of diastolic dysfunction and myocardial fibrosis in patients with Fabry disease #MMPMID30018776 Liu D; Oder D; Salinger T; Hu K; Müntze J; Weidemann F; Herrmann S; Ertl G; Wanner C; Frantz S; Störk S; Nordbeck P Open Heart 2018[]; 5 (2): ä PMID30018776show ga Objectives: Current guidelines highlight important therapy implications of cardiac fibrosis in patients with Fabry disease (FD). However, association between morphological and functional impairments with cardiac fibrosis in hereditary cardiomyopathies remains elusive. We investigated the association between echocardiography-determined cardiac dysfunction and cardiac MRI (cMRI)-detected myocardial fibrosis (late gadolinium enhancement, LE) in patients with FD with preserved left ventricular ejection fraction (?50%). Methods: 146 patients with FD (aged 39±14 years, 57 men) were analysed, all receiving echocardiography and cMRI within a 1?week interval. Longitudinal systolic strain (LS_sys), strain rate (LSr_sys) and diastolic strain rate (LSr_E/LSr_A) were assessed using speckle-tracking imaging. Receiver operating characteristic (ROC) analysis was performed to identify the diagnostic performance of various markers for LE. Results: LE was detected in 57 (39%) patients with FD. LV wall thickness, left atrial volume, septal E/e?, diastolic dysfunction grade, global LS_sys and E/LSr_E, mid-lateral LS_sys and LSr_E, as well as N-terminal pro-brain natriuretic peptide were all associated with LE independent of age, sex, body mass index, New York Heart Association functional class and kidney function. In ROC curve analysis, septal E/e? performed best (area under the curve=0.86, 95% CI=0.79 to 0.92). Septal E/e?>14.8 was strongly associated with LE (specificity=97.8%?and sensitivity=49.1%). In 9% of patients, localised LE was present even though no other cardiac or kidney abnormalities were detected. Conclusions: Echocardiography-derived diastolic dysfunction is closely linked to LE in FD. Septal E/e? ratio is the best echocardiographic marker suggestive of LE. Diastolic dysfunction is not a prerequisite for LE in FD, since LE can be detected in the absence of measurable cardiac functional impairments. Trial registration number: ClinicalTrials.gov Identifier (NCT03362164). äAssociation and diagnostic utility of diastolic dysfunction and myocar(epmc).pdf DeepDyve Pubget Overpricing