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10.1038/s41413-018-0022-y http://scihub22266oqcxt.onion/10.1038/s41413-018-0022-y C6050246!6050246!30038820     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30038820&cmd=llinks): Failed to open stream: HTTP request failed! 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Ciliary parathyroid hormone signaling activates transforming growth factor-? to maintain intervertebral disc homeostasis during aging |pdf=|usr=}}{{30038820}} gab.com Text Ciliary parathyroid hormone signaling activates transforming growth factor- to maintain intervertebral disc homeostasis during aging JO: Bone Res http://www.kidney.de/pget.php?&tw=1&pmid=30038820 #FOAvip Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor (PTH1R) to the cilia and enhances parathyroid hormone (PTH) signaling in NP cells. PTH induces transcription of integrin ?v?6 to activate the transforming growth factor (TGF)-?-connective tissue growth factor (CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH (iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-? activity, CCN2, and aggrecan. PTH1R is expressed in both mouse and human NP cells. Importantly, knockout PTH1R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. Twit Text FOAVip Ciliary parathyroid hormone signaling activates transforming growth factor- to maintain intervertebral disc homeostasis during aging ????Bone Res http://www.kidney.de/pget.php?&tw=1&pmid=30038820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30038820 #FOAvip English Wikipedia <ref>{{Cite pmid|30038820}}</ref> Ciliary parathyroid hormone signaling activates transforming growth factor-? to maintain intervertebral disc homeostasis during aging #MMPMID30038820 Zheng L; Cao Y; Ni S; Qi H; Ling Z; Xu X; Zou X; Wu T; Deng R; Hu B; Gao B; Chen H; Li Y; Zhu J; Tintani F; Demehri S; Jain A; Kebaish KM; Liao S; Séguin CA; Crane JL; Wan M; Lu H; Sponseller PD; Riley LH; Zhou X; Hu J; Cao X Bone Res 2018[]; 6 (ä): ä PMID30038820show ga Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor (PTH1R) to the cilia and enhances parathyroid hormone (PTH) signaling in NP cells. PTH induces transcription of integrin ?v?6 to activate the transforming growth factor (TGF)-?-connective tissue growth factor (CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH (iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-? activity, CCN2, and aggrecan. PTH1R is expressed in both mouse and human NP cells. Importantly, knockout PTH1R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. äCiliary parathyroid hormone signaling activates transforming growth fa(epmc).pdf DeepDyve Pubget Overpricing