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10.1186/s12979-018-0121-z http://scihub22266oqcxt.onion/10.1186/s12979-018-0121-z C6050655!6050655!30026783     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30026783&cmd=llinks): Failed to open stream: HTTP request failed! 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ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications |pdf=|usr=}}{{30026783}} gab.com Text ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications JO: Immun Ageing http://www.kidney.de/pget.php?&tw=1&pmid=30026783 #FOAvip Background: End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system. Methods: The aim of our study was to analyse whether dialysis modality may mitigate ESRD-induced immune senescence. We explored a large population of patients (675 ESRD patients) and both confirmed and refined the results in a second cohort (84 patients). Results: HD patients exhibited higher inflammatory monocytes counts (44/mm3 (1?520) vs 36/mm3 (1?161); p =?0.005). Patients on HD also had higher frequency of CD8 T cells (24% (7?61) vs 22% (8?42); p =?0.003) and reduced CD4/CD8 ratio. Such results were confirmed in the second cohort. Moreover, both CD4?+?CD57?+?CD28- (3.25% (0?38.2) vs 1.05% (0?28.5); p =?0.068) and CD8?+?CD57?+?CD28- (38.5% (3.6?76.8) vs 26.1 (2.1?46.9); p =?0.039) T cells frequencies were increased in HD patients. Telomere length did not differ according to dialysis modality, but was inversely related to ferritin levels (r =???0.33; p?=?0.003). There was a trend towards higher telomerase activity in PD patients (11?±?13 vs 6?±?11; p =?0.053). Thymic function was not different in PD and HD patients. Patients on PD before transplantation had a higher risk of acute rejection after kidney transplantation (HR, 1.61; 95%CI, 1.02 to 2.56; p =?0.041). Conclusions: More pronounced inflammation with hemodialysis may induce premature aging of the immune system. This observation correlates with a lower risk of acute kidney rejection in patients previously on HD. Clinical consequences in patients maintained on dialysis should be determined. Trial registration: Trial registration: NCT02843867, registered July 8, 2016. Twit Text FOAVip ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications ????Immun Ageing http://www.kidney.de/pget.php?&tw=1&pmid=30026783 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30026783 #FOAvip English Wikipedia <ref>{{Cite pmid|30026783}}</ref> ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications #MMPMID30026783 Ducloux D; Legendre M; Bamoulid J; Rebibou JM; Saas P; Courivaud C; Crepin T Immun Ageing 2018[]; 15 (ä): ä PMID30026783show ga Background: End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system. Methods: The aim of our study was to analyse whether dialysis modality may mitigate ESRD-induced immune senescence. We explored a large population of patients (675 ESRD patients) and both confirmed and refined the results in a second cohort (84 patients). Results: HD patients exhibited higher inflammatory monocytes counts (44/mm3 (1?520) vs 36/mm3 (1?161); p =?0.005). Patients on HD also had higher frequency of CD8 T cells (24% (7?61) vs 22% (8?42); p =?0.003) and reduced CD4/CD8 ratio. Such results were confirmed in the second cohort. Moreover, both CD4?+?CD57?+?CD28- (3.25% (0?38.2) vs 1.05% (0?28.5); p =?0.068) and CD8?+?CD57?+?CD28- (38.5% (3.6?76.8) vs 26.1 (2.1?46.9); p =?0.039) T cells frequencies were increased in HD patients. Telomere length did not differ according to dialysis modality, but was inversely related to ferritin levels (r =???0.33; p?=?0.003). There was a trend towards higher telomerase activity in PD patients (11?±?13 vs 6?±?11; p =?0.053). Thymic function was not different in PD and HD patients. Patients on PD before transplantation had a higher risk of acute rejection after kidney transplantation (HR, 1.61; 95%CI, 1.02 to 2.56; p =?0.041). Conclusions: More pronounced inflammation with hemodialysis may induce premature aging of the immune system. This observation correlates with a lower risk of acute kidney rejection in patients previously on HD. Clinical consequences in patients maintained on dialysis should be determined. Trial registration: Trial registration: NCT02843867, registered July 8, 2016. äESRD-associated immune phenotype depends on dialysis modality and iron(epmc).pdf DeepDyve Pubget Overpricing