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10.1038/s41388-018-0253-9 http://scihub22266oqcxt.onion/10.1038/s41388-018-0253-9 C6062498!6062498!29706651     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29706651&cmd=llinks): Failed to open stream: HTTP request failed! 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Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7?CYFIP1-mediated signaling pathway |pdf=|usr=}}{{29706651}} gab.com Text Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7 CYFIP1-mediated signaling pathway JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29706651 #FOAvip The early onset breast cancer patients (age???40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecules associated with poor prognosis of early onset breast cancer, we examined gene expression profiles from paired breast normal/tumor tissues, and coupled with Gene Ontology and public data base analysis. Our data showed that the expression of GAS7b gene was lower in the early onset breast cancer patients as compared to the elder patients. We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and ?1-integrin/FAK/Src signaling. We further demonstrated that p53 directly regulated GAS7 gene expression, which was inversely correlated with p53 mutations in breast cancer specimens. Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7?CYFIP1-mediated signaling pathways. Twit Text FOAVip Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7 CYFIP1-mediated signaling pathway ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29706651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29706651 #FOAvip English Wikipedia <ref>{{Cite pmid|29706651}}</ref> Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7?CYFIP1-mediated signaling pathway #MMPMID29706651 Chang JW; Kuo WH; Lin CM; Chen WL; Chan SH; Chiu MF; Chang IS; Jiang SS; Tsai FY; Chen CH; Huang PH; Chang KJ; Lin KT; Lin SC; Wang MY; Uen YH; Tu CW; Hou MF; Tsai SF; Shen CY; Tung SL; Wang LH Oncogene 2018[]; 37 (30): 4137-50 PMID29706651show ga The early onset breast cancer patients (age???40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecules associated with poor prognosis of early onset breast cancer, we examined gene expression profiles from paired breast normal/tumor tissues, and coupled with Gene Ontology and public data base analysis. Our data showed that the expression of GAS7b gene was lower in the early onset breast cancer patients as compared to the elder patients. We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and ?1-integrin/FAK/Src signaling. We further demonstrated that p53 directly regulated GAS7 gene expression, which was inversely correlated with p53 mutations in breast cancer specimens. Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7?CYFIP1-mediated signaling pathways. �Wild-type p53 upregulates an early onset breast cancer-associated gene(epmc).pdf DeepDyve Pubget Overpricing