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10.1016/B978-0-12-819460-7.00096-7

http://scihub22266oqcxt.onion/10.1016/B978-0-12-819460-7.00096-7
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C8326513!8326513!C8326513
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suck abstract from ncbi


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pmidC8326513      Encyclopedia+of+Biological+Chemistry+III 2021 ; ä (ä): 110-21
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  • Receptors | Angiotensin Receptors #MMPMIDC8326513
  • Pardhi TR; Karnik SS
  • Encyclopedia of Biological Chemistry III 2021[]; ä (ä): 110-21 PMIDC8326513show ga
  • The renin-angiotensin-aldosterone system (RAS) is a vital hormone-receptor system that regulates cardiovascular and renal functions. In this article, we discuss exciting new findings in the RAS field. Recently solved active state crystal structures of Angiotensin II type 1 (AT1R) and type 2 receptor (AT2R) helped in understanding receptor activation mechanisms in detail. Also, considerable attention is given to the developments in characterizing the counter-regulatory RAS axis due to current hope for harnessing this axis for the development of protective therapies against various cardiovascular diseases. We describe the RAS component, angiotensin-converting enzyme 2 (ACE2) functioning as cellular entry receptor for the causative agent of COVID-19 pandemic, SARS-CoV-2. Altogether, these discoveries paved the way for developing novel therapies targeting different components of the RAS in the future.
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